Search Results - andre+beauchemin

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Inhibitors of Nucleophilic Enzymes for therapeutic and drug discovery applications

These inhibitors are based on hydrazone derivatives produced using a novel synthetic route. The compounds react with the active site of nucleophilic enzyme, which typically have a nucleophile such as an amine, alcohol, or thiol on the side chain (for example - lysine, serine, and cysteine). In reacting at this site, the enzyme is inhibited. Such inhibition...

Published: 11/18/2015 | Updated: 7/19/2013 | Inventor(s): Andre Beauchemin, Keira Garland, Alison Sherratt, John Pezacki

Keywords(s):

Category(s): Bio-Tech, Chemistry, Life Sciences

Efficient synthesis of synthetic peptides containing beta-aminocarbonyls

Beta-aminocarbonyls are found in several major drugs and are increasingly important in synthetic peptides. This method reduces the cost of synthesizing beta-aminocarbonyl structures by reducing the number of steps in the synthesis, and using low cost starting reagents. It can also be easily scaled from the bench to the manufacturing process.

Published: 11/18/2015 | Updated: 7/19/2013 | Inventor(s): Andre Beauchemin, Wei Gan, Christian Clavette, Tom Markiewicz, Amy Toderian

Keywords(s): Other

Category(s): Bio-Tech, Chemistry, Life Sciences, Manufacturing & Materials

Stable and Low cost Peptides; Improved Synthesis of Natural and Synthetic Amino Acids

This one step reaction to amino acids and their derivatives uses inexpensive starting material. It can be used for developing simple synthetic routes to inexpensive natural and synthetic proteins for pharmaceuticals, agrochemicals, and research needs. Synthetic derivatives retain activity, while protecting the peptides from damaging enzymes. Description:...

Published: 11/18/2015 | Updated: 7/3/2013 | Inventor(s): Andre Beauchemin, Christian Clavette, Jean-Francois Vincent-Rocan

Keywords(s): Health, Molecular and Environmental Sciences

Category(s): Chemistry, Life Sciences, Manufacturing & Materials, Sustainable Technology, Bio-Tech