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Inhibitors of Nucleophilic Enzymes for therapeutic and drug discovery applications

These inhibitors are based on hydrazone derivatives produced using a novel synthetic route. The compounds react with the active site of nucleophilic enzyme, which typically have a nucleophile such as an amine, alcohol, or thiol on the side chain (for example - lysine, serine, and cysteine). In reacting at this site, the enzyme is inhibited. Such inhibition...

Published: 11/18/2015 | Updated: 7/19/2013 | Inventor(s): Andre Beauchemin, Keira Garland, Alison Sherratt, John Pezacki

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Category(s): Bio-Tech, Chemistry, Life Sciences